Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406588 | 0.80 | EGLN1 (0.66) | MEN1KMT2AEGLN1KCNH2CYP1A2 | |
| SCHEMBL3409150 | 0.79 | EGLN1 (0.56) | EGLN1 | |
| SCHEMBL3410878 | 0.79 | EGLN1 (0.63) | EGLN1 | |
| SCHEMBL4525793 | 0.79 | EGLN1 (0.66) | MEN1KMT2AEGLN1KCNH2CYP1A2 | |
| SCHEMBL3409230 | 0.79 | EGLN1 (0.55) | EGLN1KDM4EALDH1A1PDE2A | |
| SCHEMBL3435037 | 0.78 | EGLN1 (0.45) | MEN1KMT2AEGLN1CYP1A2CYP2C19 | |
| SCHEMBL3404173 | 0.77 | EGLN1 (0.43) | EGLN1CYP1A2CYP2C19KDM4EMAPT | |
| SCHEMBL14812785 | 0.77 | EGLN1 (0.52) | MEN1KMT2AEGLN1KCNH2CYP1A2 | |
| SCHEMBL4530398 | 0.76 | EGLN1 (0.50) | EGLN1PDE2AKAT6A | |
| SCHEMBL12288011 | 0.76 | KMT2A (0.57) | MEN1KMT2AEGLN1KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |