Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GYS1 | P13807 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404884 | 0.85 | HTR2C (0.43) | HTR2CALDH1A1TP53SMN1; SMN2PPARA | |
| SCHEMBL3404806 | 0.83 | HTR2C (0.41) | HTR2CKMT2AALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL3404998 | 0.82 | HTR2C (0.47) | HTR2CCTSAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3402113 | 0.82 | HTR2C (0.47) | HTR2CKMT2AALDH1A1MEN1 | |
| SCHEMBL3399781 | 0.81 | HTR2C (0.46) | HTR2CKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3405451 | 0.81 | HTR2C (0.43) | HTR2CKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3402536 | 0.80 | HTR2C (0.52) | HTR2CKMT2AALDH1A1SMN1; SMN2RAD52 | |
| SCHEMBL3405730 | 0.80 | HTR2C (0.46) | HTR2CCTSAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL3400089 | 0.80 | HTR2C (0.49) | HTR2CKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3405734 | 0.80 | PPARD (0.46) | HTR2CALDH1A1TP53SMN1; SMN2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |