Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 6/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26124133 | 0.98 | DPP7 (0.43) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL16197317 | 0.78 | CYP1A2 (0.46) | HPGD | |
| Hydrochloric Acid SCHEMBL3402038 | 0.77 | CYP1A2 (0.45) | HPGD | |
| SCHEMBL28197935 | 0.76 | DPP7 (0.48) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL3733207 | 0.76 | DPP7 (0.44) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL21896200 | 0.75 | DPP7 (0.41) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL856280 | 0.74 | DPP4 (0.46) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL5891316 | 0.74 | DPP4 (0.46) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL8612552 | 0.74 | DPP4 (0.46) | DPP7ALDH1A1DPP4MMP1MMP2 | |
| SCHEMBL16935735 | 0.74 | DPP4 (0.46) | DPP7ALDH1A1DPP4MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378092-B2 | Chlorothiophene-amides as inhibitors of coagulation factors Xa and thrombin | SANOFI (FR) | 2013-02-19 | — | — | US | disclosed |
| EP-2254881-B1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI SA (FR) | 2012-09-12 | — | — | EP | disclosed |
| EP-2254881-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009103440-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI-AVENTIS (FR) | 2009-08-27 | — | — | WO | disclosed |