Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | POLR1A | O95602 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396816 | 0.94 | HPGD (0.57) | HPGDACHECD274MAPTALDH1A1 | |
| SCHEMBL3405531 | 0.84 | CHRM4 (0.49) | HPGDMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3399568 | 0.83 | CHRM4 (0.51) | HPGDSMN1; SMN2ALDH1A1NPC1CHRM4 | |
| SCHEMBL3400096 | 0.83 | CHRM4 (0.49) | HPGDMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3406027 | 0.82 | CHRM4 (0.50) | HPGDSMN1; SMN2ALDH1A1NPC1CHRM4 | |
| SCHEMBL3400929 | 0.82 | SCN9A (0.49) | HPGDMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3398394 | 0.82 | KDM4E (0.54) | ACHEMAPTALDH1A1CHRM4LMNA | |
| SCHEMBL3403888 | 0.82 | MAPT (0.53) | MAPTSMN1; SMN2NPC1LMNATP53 | |
| SCHEMBL3403441 | 0.81 | NPSR1 (0.51) | HPGDMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3398904 | 0.81 | POLB (0.60) | HPGDACHEMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |