Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398394 | 0.92 | KDM4E (0.54) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3404897 | 0.92 | ACHE (0.54) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3399700 | 0.91 | KDM4E (0.56) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3405206 | 0.91 | GLA (0.60) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3398969 | 0.91 | HPGD (0.55) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3398806 | 0.90 | CHRM4 (0.54) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3406028 | 0.89 | GLA (0.50) | POLBMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3401424 | 0.89 | PPARA (0.61) | POLBALDH1A1PPARACHRM4PPARD | |
| SCHEMBL3405464 | 0.88 | PPARA (0.60) | POLBALDH1A1PPARACHRM4PPARD | |
| SCHEMBL3403888 | 0.88 | MAPT (0.53) | POLBMAPTLMNATP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |