Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398386 | 0.91 | THRA (0.43) | THRATHRBHRH3LMNACNR1 | |
| SCHEMBL3400494 | 0.90 | THRA (0.45) | THRATHRBHRH3ALDH1A1CNR1 | |
| SCHEMBL3405660 | 0.90 | THRA (0.45) | THRATHRBHRH3ALDH1A1CNR1 | |
| SCHEMBL3398458 | 0.88 | THRA (0.43) | PDE4APDE4BTHRATHRBHRH3 | |
| SCHEMBL3403653 | 0.88 | THRA (0.45) | THRATHRBHRH3CNR1PARP1 | |
| SCHEMBL3403866 | 0.87 | HTR2C (0.41) | HRH3KDM4EALDH1A1LMNACNR1 | |
| SCHEMBL3402959 | 0.87 | HRH3 (0.46) | THRATHRBHRH3KDM4EALDH1A1 | |
| SCHEMBL3406091 | 0.86 | HTR2C (0.42) | KDM4EALDH1A1LMNASLC29A1HTR2C | |
| SCHEMBL3400840 | 0.86 | THRA (0.43) | THRATHRBHRH3KDM4EALDH1A1 | |
| SCHEMBL3401274 | 0.86 | SLC29A1 (0.47) | THRATHRBHRH3LMNACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |