Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 4/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 3/20 | 0.35 |
| ▸ | PLAT | P00750 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.33 |
| ▸ | AGXT | P21549 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395701 | 0.88 | PLG (0.39) | CTSAFFAR1PLGPLAUPLAT | |
| SCHEMBL4095280 | 0.81 | TACR1 (0.44) | GRM2FFAR1TACR1DHODHENPP2 | |
| SCHEMBL3396510 | 0.76 | CTSA (0.36) | CTSAFFAR1TACR1 | |
| SCHEMBL1363777 | 0.75 | GRM2 (0.37) | GRM2FFAR1TACR1DHODHENPP2 | |
| SCHEMBL12053374 | 0.74 | TACR1 (0.41) | GRM2TACR1ENPP2PTGER2 | |
| SCHEMBL4103863 | 0.72 | TACR1 (0.44) | FFAR1TACR1DHODHPTGER2 | |
| SCHEMBL1362377 | 0.72 | AGXT (0.39) | GRM5PLGPLAUPLATPTGER2 | |
| SCHEMBL4093359 | 0.70 | MAPT (0.42) | TACR1PTGER2 | |
| SCHEMBL4098806 | 0.70 | CHRM3 (0.41) | FFAR1TACR1PTGER2 | |
| SCHEMBL4783563 | 0.70 | PRKCI (0.49) | GRM2AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249647-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |