Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402068 | 0.94 | HTR2C (0.47) | HTR2CCNR1PARP1HRH3CES2 | |
| SCHEMBL3398932 | 0.92 | HTR2C (0.47) | HTR2CCNR1PARP1CES2THRA | |
| SCHEMBL3406038 | 0.92 | HTR2C (0.47) | HTR2CCNR1PARP1HRH3CES2 | |
| SCHEMBL3396826 | 0.90 | HTR2C (0.46) | HTR2CCNR1PARP1HRH3CYP3A4 | |
| SCHEMBL3407762 | 0.89 | HTR2C (0.47) | HTR2CCNR1PARP1HRH3CES2 | |
| SCHEMBL3400042 | 0.88 | HTR2C (0.58) | HTR2CCNR1PARP1HRH3CES2 | |
| SCHEMBL3404343 | 0.87 | HTR2C (0.47) | HTR2CCNR1PARP1CES2THRA | |
| SCHEMBL3401691 | 0.86 | HTR2C (0.45) | HTR2CCNR1HRH3 | |
| SCHEMBL3399685 | 0.84 | CNR1 (0.55) | HTR2CCNR1HRH3RAB9ATRPM8 | |
| SCHEMBL3403332 | 0.83 | HTR2C (0.55) | HTR2CCNR1PARP1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |