Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407762 | 0.92 | HTR2C (0.47) | HTR2CCNR1HRH3CES2PARP1 | |
| SCHEMBL3405067 | 0.92 | HTR2C (0.47) | HTR2CCNR1HRH3CES2PARP1 | |
| SCHEMBL3402068 | 0.89 | HTR2C (0.47) | HTR2CCNR1HRH3CES2PARP1 | |
| SCHEMBL3404163 | 0.87 | HTR2C (0.47) | HTR2CCNR1HRH3CES2 | |
| SCHEMBL3404031 | 0.86 | HTR2C (0.47) | HTR2CCNR1HRH3CES2 | |
| SCHEMBL3401691 | 0.86 | HTR2C (0.45) | HTR2CCNR1HRH3 | |
| SCHEMBL3404209 | 0.85 | HTR2C (0.49) | HTR2CCNR1HRH3CES2PARP1 | |
| SCHEMBL3400446 | 0.85 | HTR2C (0.44) | HTR2CCNR1HRH3CES2PARP1 | |
| SCHEMBL3400087 | 0.85 | HTR2C (0.47) | HTR2CCNR1HRH3CES2PARP1 | |
| SCHEMBL3398932 | 0.85 | HTR2C (0.47) | HTR2CCNR1CES2PARP1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |