Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.51 |
| ▸ | AR | P10275 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405195 | 1.00 | NR3C1 (0.62) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL13102597 | 0.92 | NR3C1 (0.52) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL3403608 | 0.84 | NR3C1 (0.57) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL3403600 | 0.84 | NR3C1 (0.57) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL3403162 | 0.82 | NR3C1 (0.67) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL13102567 | 0.79 | NR3C1 (0.56) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL20169813 | 0.79 | NR3C1 (0.45) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL16614002 | 0.79 | NR3C1 (0.45) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL16613911 | 0.79 | NR3C1 (0.45) | NR3C1CYP3A4HIF1AARHSD17B10 | |
| SCHEMBL11347083 | 0.78 | NR3C1 (0.72) | NR3C1CYP3A4HIF1AARHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414377-B1 | NOVEL DERIVATIVES OF STEROIDAL [3,2-C] PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2016-01-06 | — | — | EP | disclosed |
| US-8338587-B2 | Compounds | ASTRAZENECA AB | 2012-12-25 | — | — | US | disclosed |
| US-20100256103-A1 | NOVEL COMPOUNDS | ASTRAZENECA R&D (SE) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256103-A1 | NOVEL COMPOUNDS | SLC10A1, ABCB1, UGT1A1 | NR3C1 858/4885CYP3A4 87/4885HIF1A 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.