Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502259 | 1.00 | HTR4 (0.56) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL3404390 | 1.00 | HTR4 (0.56) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL8002090 | 0.95 | HTR4 (0.55) | HTR4KCNH2DRD3DRD2DRD4 | |
| SCHEMBL3402350 | 0.93 | KCNH2 (0.63) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL1502106 | 0.93 | KCNH2 (0.63) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL3408390 | 0.93 | KCNH2 (0.63) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL1502057 | 0.92 | KCNH2 (0.51) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL1501959 | 0.91 | KCNH2 (0.56) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL1502007 | 0.91 | HTR4 (0.58) | HTR4KCNH2DRD3MEN1LMNA | |
| SCHEMBL1502296 | 0.90 | KCNH2 (0.53) | HTR4KCNH2DRD3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256114-B1 | AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | DAINIPPON SUMITOMO PHARMA CO (JP) | 2014-06-25 | — | — | EP | disclosed |
| EP-2256114-A1 | AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-12-01 | — | — | EP | disclosed |