Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | POLR1A | O95602 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401863 | 0.94 | HTR2C (0.56) | HTR2CCES2CNR1LMNA | |
| SCHEMBL3405158 | 0.89 | HTR2C (0.50) | HTR2CJAK1POLR1ACNR1 | |
| SCHEMBL3399761 | 0.88 | HTR2C (0.53) | HTR2CJAK1POLR1ACES2CNR1 | |
| SCHEMBL3404740 | 0.87 | HTR2C (0.52) | HTR2CJAK1POLR1ACES2CNR1 | |
| SCHEMBL3405397 | 0.86 | HTR2C (0.50) | HTR2CJAK1POLR1ACES2CNR1 | |
| SCHEMBL3402535 | 0.86 | HTR2C (0.52) | HTR2CJAK1POLR1ACES2CNR1 | |
| SCHEMBL3405059 | 0.86 | HTR2C (0.56) | HTR2CCES2CNR1LMNA | |
| SCHEMBL3405032 | 0.85 | HTR2C (0.69) | HTR2CPOLR1ACES2 | |
| SCHEMBL3404419 | 0.85 | HTR2C (0.51) | HTR2CJAK1POLR1ACES2CNR1 | |
| SCHEMBL3402532 | 0.84 | HTR2C (0.52) | HTR2CJAK1POLR1ACES2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |