Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | POLR1A | O95602 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401147 | 0.94 | HTR2C (0.55) | HTR2CMCHR1PPARDPPARACES2 | |
| SCHEMBL3399761 | 0.89 | HTR2C (0.53) | HTR2CMCHR1POLR1ACES2CNR1 | |
| SCHEMBL3402583 | 0.89 | HTR2C (0.53) | HTR2CMCHR1PPARDPPARASCD5 | |
| SCHEMBL3404740 | 0.89 | HTR2C (0.52) | HTR2CPOLR1ACES2CNR1JAK1 | |
| SCHEMBL3402535 | 0.88 | HTR2C (0.52) | HTR2CMCHR1PPARDPPARAPOLR1A | |
| SCHEMBL3405032 | 0.87 | HTR2C (0.69) | HTR2CPOLR1ACES2 | |
| SCHEMBL3400812 | 0.87 | HTR2C (0.53) | HTR2CMCHR1PPARDPPARACES2 | |
| SCHEMBL3405397 | 0.86 | HTR2C (0.50) | HTR2CPOLR1ACES2CNR1JAK1 | |
| SCHEMBL3402532 | 0.86 | HTR2C (0.52) | HTR2CPOLR1ACES2CNR1JAK1 | |
| SCHEMBL3405482 | 0.85 | HTR2C (0.52) | HTR2CPOLR1ACES2CNR1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |