Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3429158 | 0.94 | GLA (0.51) | ALDH1A1MAPTNPC1HPGDGAA | |
| SCHEMBL3429141 | 0.93 | GLA (0.50) | ALDH1A1TSHRMAPTNPC1HPGD | |
| SCHEMBL3404144 | 0.88 | PPARA (0.47) | MAPTNPC1HPGDHTR1AHTR2A | |
| SCHEMBL3402374 | 0.87 | SMYD2 (0.49) | NPC1HPGDHTR1AHTR2ADRD3 | |
| SCHEMBL3401173 | 0.85 | MAPT (0.50) | MAPTNPC1HPGDHTR1AHTR2A | |
| SCHEMBL3405815 | 0.85 | MAPT (0.52) | MAPTNPC1HPGDSMYD2 | |
| SCHEMBL3398623 | 0.85 | SMYD2 (0.52) | MAPTNPC1HPGDHTR1AHTR2A | |
| SCHEMBL3403357 | 0.84 | DRD3 (0.49) | TSHRNPC1HPGDHTR1AHTR2A | |
| SCHEMBL3400521 | 0.84 | GAA (0.45) | ALDH1A1MAPTNPC1HPGDHTR1A | |
| SCHEMBL3399687 | 0.84 | CHRM4 (0.52) | ALDH1A1MAPTNPC1HPGDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |