Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402472 | 0.94 | HPGD (0.47) | GAANPC1HPGDSMYD2CHRM4 | |
| SCHEMBL3405410 | 0.93 | HPGD (0.47) | GAANPC1HPGDCHRM4SMN1; SMN2 | |
| SCHEMBL3401173 | 0.87 | MAPT (0.50) | GAANPC1HPGDSMYD2CHRM4 | |
| SCHEMBL3398623 | 0.86 | SMYD2 (0.52) | GAANPC1HPGDSMYD2DRD3 | |
| SCHEMBL13309646 | 0.85 | HPGD (0.47) | GAANPC1HPGDCHRM4SMN1; SMN2 | |
| SCHEMBL3403850 | 0.85 | ALDH1A1 (0.57) | GAANPC1HPGDSMYD2CHRM4 | |
| SCHEMBL3401375 | 0.85 | SMYD2 (0.51) | GAANPC1HPGDSMYD2CHRM4 | |
| SCHEMBL3402848 | 0.85 | LMNA (0.52) | NPC1HRH3MAPTTP53 | |
| SCHEMBL3403357 | 0.84 | DRD3 (0.49) | GAANPC1HPGDSMYD2CHRM4 | |
| SCHEMBL3405754 | 0.84 | ALDH1A1 (0.47) | GAANPC1HPGDSMYD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |