Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.50 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402296 | 0.86 | TP53 (0.75) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL25334300 | 0.84 | TP53 (0.68) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL3400622 | 0.83 | TP53 (0.66) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL6280740 | 0.80 | TP53 (1.00) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL3406655 | 0.80 | POLB (0.62) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL3406954 | 0.80 | ALOX12 (0.69) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL3406737 | 0.79 | TP53 (0.64) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL19211363 | 0.77 | TP53 (0.58) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL15882211 | 0.77 | SMN1; SMN2 (0.77) | TP53ALOX12MAPTKMT2AHPGD | |
| SCHEMBL3407149 | 0.76 | TP53 (0.57) | TP53ALOX12MAPTKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |