Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | POLR1A | O95602 | 1/20 | 0.40 |
| ▸ | CBX7 | O95931 | 1/20 | 0.39 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400092 | 0.94 | HTR2C (0.47) | HTR2CACKR3CBX7CDYL2CDYL | |
| SCHEMBL3405850 | 0.93 | HTR2C (0.44) | HTR2CACKR3POLR1ACBX7CDYL2 | |
| SCHEMBL3401299 | 0.92 | ACKR3 (0.47) | HTR2CACKR3POLR1ACBX7CDYL2 | |
| SCHEMBL3399783 | 0.91 | HTR2C (0.45) | HTR2CPOLR1ATHRATHRBCES2 | |
| SCHEMBL3400020 | 0.89 | HTR2C (0.41) | HTR2CACKR3POLR1A | |
| SCHEMBL3401811 | 0.88 | HTR2C (0.45) | HTR2CPOLR1ATHRATHRBCES2 | |
| SCHEMBL3405458 | 0.87 | HTR2C (0.47) | HTR2CACKR3CBX7CDYL2CDYL | |
| SCHEMBL3401129 | 0.87 | ACKR3 (0.50) | HTR2CACKR3CBX7CDYL2CDYL | |
| SCHEMBL3399761 | 0.87 | HTR2C (0.53) | HTR2CPOLR1ACES2 | |
| SCHEMBL13310351 | 0.86 | HTR2C (0.46) | HTR2CACKR3CBX7CDYL2CDYL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |