Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405880 | 0.76 | TMIGD3 (0.30) | — | |
| SCHEMBL3320276 | 0.72 | ADORA2A (0.40) | PDE8B | |
| SCHEMBL3321834 | 0.72 | PDE5A (0.40) | PDE8B | |
| SCHEMBL2198368 | 0.67 | PDE8B (0.42) | PDE8B | |
| SCHEMBL2198895 | 0.66 | TLR7 (0.45) | PDE8B | |
| SCHEMBL5163571 | 0.59 | ADORA1 (0.67) | — | |
| SCHEMBL1848717 | 0.58 | ADORA2A (0.35) | PDE8B | |
| SCHEMBL3378114 | 0.58 | ADORA2A (0.35) | PDE8B | |
| SCHEMBL16882930 | 0.58 | ADORA2A (0.35) | PDE8B | |
| SCHEMBL5163706 | 0.58 | ADORA2A (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125792-B1 | PURINE DERIVATIVES AS IMMUNOMODULATORS | GLAXOSMITHKLINE LLC (US) | 2010-12-01 | — | — | EP | disclosed |