Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405878 | 0.76 | PDE8B (0.31) | — | |
| SCHEMBL3320276 | 0.74 | ADORA2A (0.40) | TMIGD3ADORA2AADORA2BADORA1 | |
| SCHEMBL3321834 | 0.73 | PDE5A (0.40) | TMIGD3ADORA2AADORA2BADORA1 | |
| SCHEMBL2198368 | 0.68 | PDE8B (0.42) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2198895 | 0.67 | TLR7 (0.45) | ADORA2AADORA2BADORA1 | |
| SCHEMBL5163571 | 0.60 | ADORA1 (0.67) | TMIGD3ADORA2AADORA2BADORA1 | |
| SCHEMBL5163706 | 0.59 | ADORA2A (0.68) | TMIGD3ADORA2AADORA2BADORA1 | |
| SCHEMBL2199449 | 0.58 | PDE8B (0.40) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2196854 | 0.58 | TLR7 (0.47) | TMIGD3ADORA2AADORA2BADORA1 | |
| SCHEMBL2201635 | 0.57 | TLR7 (0.44) | TMIGD3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125792-B1 | PURINE DERIVATIVES AS IMMUNOMODULATORS | GLAXOSMITHKLINE LLC (US) | 2010-12-01 | — | — | EP | disclosed |