Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401399 | 0.82 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL3398364 | 0.82 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL3402312 | 0.79 | HTR2C (0.43) | ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL3399827 | 0.79 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL3403662 | 0.77 | ACACB (0.44) | ALDH1A1KDM4ELMNASMN1; SMN2POLB | |
| SCHEMBL3401099 | 0.77 | GAA (0.43) | ALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL3404354 | 0.77 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL3400861 | 0.75 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL3403443 | 0.74 | SIGMAR1 (0.47) | SIGMAR1ALDH1A1KDM4ETP53DRD4 | |
| SCHEMBL3396848 | 0.73 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |