Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.49 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 9/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3972256 | 0.88 | CXCR4 (0.44) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL13764390 | 0.88 | MAPT (0.68) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL2831556 | 0.88 | MAPT (0.68) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL10261442 | 0.86 | MAPT (0.70) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL29444010 | 0.82 | MAPT (0.67) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL8527380 | 0.82 | MAPT (0.72) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL4216543 | 0.80 | MAPT (0.56) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL4094117 | 0.78 | CXCR4 (0.50) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL2474794 | 0.78 | CXCR4 (0.50) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 | |
| SCHEMBL6864020 | 0.75 | MAPT (0.85) | MAPTSMN1; SMN2LIN28ATDP1CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2823826-A2 | Inhibitors of carbonic anhydrase IX | Molecular Insight Pharmaceuticals, Inc. (US) | 2015-01-14 | — | — | EP | disclosed |
| US-8877970-B2 | Inhibitors of carbonic anhydrase IX | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2014-11-04 | — | — | US | disclosed |
| EP-2240171-A2 | INHIBITORS OF CARBONIC ANHYDRASE IX | Molecular Insight Pharmaceuticals, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089383-A2 | INHIBITORS OF CARBONIC ANHYDRASE IX | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
| US-20090175794-A1 | INHIBITORS OF CARBONIC ANHYDRASE IX | MOLECULAR INSIGHT PHARMACEUTICALS, INC. | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175794-A1 | INHIBITORS OF CARBONIC ANHYDRASE IX | CA9, CA12, CA1 | CHRM2 4757/4885CHRM4 4783/4885CHRM5 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.