Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 4/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400633 | 0.85 | NOTUM (0.40) | ALDH1A1HSD17B10HPGDCDC7DBF4 | |
| SCHEMBL3401335 | 0.78 | ALDH1A1 (0.60) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL404952 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL509072 | 0.77 | CDC7 (0.62) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL404561 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL18236334 | 0.77 | ALDH1A1 (0.69) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL3434666 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL3406257 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL509415 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HSD17B10CYP1A2FBP1HPGD | |
| SCHEMBL3406707 | 0.76 | ALDH1A1 (0.60) | ALDH1A1HSD17B10CYP1A2FBP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158199-B1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2010-11-17 | — | — | EP | disclosed |
| EP-2158199-B1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2010-11-17 | — | — | EP | disclosed |
| WO-2008152418-A1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | WO | disclosed |