Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.44 |
| ▸ | THRA | P10827 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 5/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 4/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523239 | 0.88 | EGLN1 (0.50) | EGLN1THRATHRBPRKAB2PRKAG1 | |
| SCHEMBL522422 | 0.83 | EGLN1 (0.45) | EGLN1THRATHRBPRKAB2PRKAG1 | |
| SCHEMBL28095852 | 0.81 | EGLN1 (0.52) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL522261 | 0.81 | EGLN1 (0.47) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL522160 | 0.80 | EGLN1 (0.43) | EGLN1THRATHRBPRKAB2PRKAG1 | |
| SCHEMBL523053 | 0.78 | EGLN1 (0.43) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL521928 | 0.77 | EGLN1 (0.53) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL523849 | 0.77 | EGLN1 (0.43) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL522268 | 0.76 | THRA (0.72) | EGLN1THRATHRBBBOX1FTO | |
| SCHEMBL5143765 | 0.76 | EGLN1 (0.44) | EGLN1THRATHRBPRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919463-B1 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN INC (US) | 2010-06-09 | — | — | EP | disclosed |