Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.64 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 5/20 | 0.38 |
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 4/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138260 | 0.82 | OPRL1 (0.78) | OPRL1OPRM1KDM1AOPRK1SLC6A2 | |
| SCHEMBL3409102 | 0.82 | OPRL1 (0.61) | OPRL1OPRM1KDM1ACTSSCTSK | |
| SCHEMBL3411324 | 0.78 | OPRL1 (1.00) | OPRL1OPRM1KDM1AOPRK1SLC6A2 | |
| SCHEMBL4348241 | 0.73 | OPRL1 (0.60) | OPRL1OPRM1KDM1AOPRK1SLC6A2 | |
| SCHEMBL3407538 | 0.73 | OPRM1 (0.42) | OPRL1OPRM1CTSSCTSKCTSL | |
| SCHEMBL3408991 | 0.73 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3413567 | 0.71 | OPRL1 (0.61) | OPRL1OPRM1KDM1AOPRK1SLC6A2 | |
| SCHEMBL3413008 | 0.71 | OPRL1 (0.61) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4352487 | 0.70 | OPRL1 (0.60) | OPRL1OPRM1KDM1AOPRK1SLC6A2 | |
| SCHEMBL5242605 | 0.69 | OPRM1 (0.60) | OPRL1OPRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502907-B1 | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2018-08-29 | — | — | EP | disclosed |
| EP-2518052-B1 | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| EP-2260021-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2014-04-23 | — | — | EP | disclosed |
| EP-2518052-A1 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2502907-A1 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |
| EP-2260021-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118168-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |