Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 12/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431021 | 0.80 | HCRTR2 (0.48) | HCRTR2HCRTR1CAPN1KMT2ALMNA | |
| SCHEMBL30516085 | 0.80 | HCRTR2 (0.53) | HCRTR2HCRTR1CAPN1KMT2AEGLN1 | |
| SCHEMBL3410075 | 0.77 | KMT2A (0.37) | HCRTR2HCRTR1KMT2AEGLN1KDM4E | |
| SCHEMBL16544035 | 0.72 | HCRTR2 (0.49) | HCRTR2HCRTR1CAPN1KMT2AKDM4E | |
| SCHEMBL29551359 | 0.72 | MYC (0.57) | HCRTR2HCRTR1CAPN1KMT2AKDM4E | |
| SCHEMBL7090852 | 0.72 | MYC (0.57) | HCRTR2HCRTR1CAPN1KMT2AKDM4E | |
| SCHEMBL29551168 | 0.70 | CAPN1 (0.55) | HCRTR2HCRTR1CAPN1KDM4ELMNA | |
| SCHEMBL5663804 | 0.70 | CAPN1 (0.55) | HCRTR2HCRTR1CAPN1KDM4ELMNA | |
| SCHEMBL14232737 | 0.69 | HCRTR2 (0.52) | HCRTR2HCRTR1CAPN1KMT2ALMNA | |
| SCHEMBL19564476 | 0.69 | CAPN1 (0.49) | HCRTR2HCRTR1CAPN1KMT2AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |