SCHEMBL3407219

SCHEMBL3407219

CC(C)(C)N(C(=O)O)C(C(=O)Nc1ccc2cnccc2c1)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 17/20 0.62
ROCK1 Q13464 2/20 0.62
IMPDH2 P12268 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1095866 1.00 ROCK2 (0.62) ROCK2ROCK1IMPDH2
SCHEMBL6717793 0.88 KMT2A (0.50) ROCK2ROCK1
SCHEMBL1096425 0.85 ROCK2 (0.69) ROCK2ROCK1IMPDH2
SCHEMBL1096422 0.85 ROCK2 (0.69) ROCK2ROCK1IMPDH2
Hydrochloric Acid SCHEMBL1096282 0.84 ROCK2 (0.67) ROCK2ROCK1IMPDH2
Hydrochloric Acid SCHEMBL1095428 0.84 ROCK2 (0.67) ROCK2ROCK1IMPDH2
Hydrochloric Acid SCHEMBL1095425 0.84 ROCK2 (0.67) ROCK2ROCK1IMPDH2
SCHEMBL14642165 0.83 ROCK2 (0.65) ROCK2ROCK1IMPDH2
SCHEMBL1098258 0.82 ROCK2 (0.58) ROCK2ROCK1IMPDH2
SCHEMBL1098257 0.82 ROCK2 (0.58) ROCK2ROCK1IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2546238-A1 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME AERIE PHARMACEUTICALS, INC. (US) 2013-01-16 EP disclosed
EP-2546239-A1 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME AERIE PHARMACEUTICALS, INC. (US) 2013-01-16 EP disclosed
EP-2546237-A1 7-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME AERIE PHARMACEUTICALS, INC. (US) 2013-01-16 EP disclosed
EP-2252589-B1 6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME AERIE PHARMACEUTICALS INC (US) 2012-11-21 EP disclosed
EP-2252589-A2 6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME Aerie Pharmaceuticals, Inc. (US) 2010-11-24 EP disclosed
WO-2009091898-A2 6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME AERIE PHARMACEUTICALS, INC. (US) 2009-07-23 WO disclosed