Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403988 | 0.90 | SMN1; SMN2 (0.64) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3403675 | 0.90 | MAPT (0.78) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3400890 | 0.90 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3407140 | 0.89 | MAPT (0.60) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL8001635 | 0.87 | MAPT (0.58) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3404049 | 0.87 | MAPT (0.55) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3406096 | 0.87 | MAPT (0.62) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL7997003 | 0.86 | TP53 (0.55) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL3405841 | 0.85 | MEN1 (0.53) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL7986777 | 0.85 | MEN1 (0.60) | MAPTSMN1; SMN2LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | claimed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | claimed |
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |