Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMURF1 | Q9HCE7 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407265 | 0.86 | MAPT (0.65) | TP53SMN1; SMN2MAPTPTGS2RIPK1 | |
| SCHEMBL17923441 | 0.82 | RIPK1 (0.44) | TP53SMN1; SMN2MAPTPTGS2RIPK1 | |
| SCHEMBL3400890 | 0.80 | SMN1; SMN2 (0.65) | TP53SMN1; SMN2MAPTPTGS2RIPK1 | |
| SCHEMBL7987917 | 0.78 | TP53 (0.57) | TP53SMN1; SMN2MAPTPTGS2MET | |
| SCHEMBL3405011 | 0.78 | MET (0.59) | TP53SMN1; SMN2MAPTPTGS2MET | |
| SCHEMBL3403988 | 0.76 | SMN1; SMN2 (0.64) | TP53SMN1; SMN2MAPTRIPK1LMNA | |
| SCHEMBL3398194 | 0.76 | TP53 (0.55) | TP53SMN1; SMN2MAPTPTGS2MET | |
| SCHEMBL13754541 | 0.76 | PTGS2 (0.71) | TP53SMN1; SMN2MAPTPTGS2MET | |
| SCHEMBL8001635 | 0.76 | MAPT (0.58) | TP53SMN1; SMN2MAPTRIPK1MET | |
| SCHEMBL3407140 | 0.75 | MAPT (0.60) | TP53SMN1; SMN2MAPTRIPK1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |