Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 2/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407279 | 1.00 | MAPT (0.48) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411810 | 0.84 | MAPT (0.55) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411804 | 0.84 | MAPT (0.55) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411881 | 0.77 | KMT2A (0.50) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411884 | 0.77 | KMT2A (0.50) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411788 | 0.77 | MAPT (0.60) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411783 | 0.77 | MAPT (0.60) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3411760 | 0.71 | MAPT (0.59) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3413627 | 0.71 | MAPT (0.46) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL3409245 | 0.67 | MEN1 (0.50) | MAPTTDP1L3MBTL1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |