SCHEMBL3409245

SCHEMBL3409245

Nc1c(=O)[nH]n2c(=O)c3c([nH]c12)CCCC3

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 9/20 0.50
KMT2A Q03164 9/20 0.50
MAPT P10636 8/20 0.50
TDP1 Q9NUW8 5/20 0.50
L3MBTL1 Q9Y468 4/20 0.50
KDM4E B2RXH2 3/20 0.50
ALPL P05186 2/20 0.50
ALPI P09923 2/20 0.50
ALPG P10696 2/20 0.50
GAA P10253 2/20 0.50
HKDC1 Q2TB90 1/20 0.50
POLB P06746 6/20 0.47
HPGD P15428 5/20 0.47
LMNA P02545 5/20 0.47
HTT P42858 3/20 0.47
CRHBP P24387 2/20 0.47
CRHR2 Q13324 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
BLM P54132 2/20 0.47
CTDSP1 Q9GZU7 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3408224 0.77 MAPT (0.50) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3411760 0.74 MAPT (0.59) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3411810 0.70 MAPT (0.55) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3411804 0.70 MAPT (0.55) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3411734 0.70 LMNA (0.58) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3414271 0.69 MAPT (0.46) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3411884 0.69 KMT2A (0.50) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3411881 0.69 KMT2A (0.50) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3405825 0.68 MAPT (0.55) MEN1KMT2AMAPTTDP1L3MBTL1
SCHEMBL3410031 0.68 MAPT (0.52) MEN1KMT2AMAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2264035-A1 Glycine B antagonists Merz Pharma GmbH & Co. KGaA (DE) 2010-12-22 EP disclosed