Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 4/20 | 0.36 |
| ▸ | SNCA | P37840 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098134 | 0.89 | NAMPT (0.49) | NAMPTLMNAOGASNCAHDAC3 | |
| SCHEMBL3408635 | 0.83 | NAMPT (0.50) | NAMPTSNCAHDAC3HDAC4HDAC1 | |
| SCHEMBL2299341 | 0.82 | NAMPT (0.54) | NAMPTLMNAOGASNCAHDAC3 | |
| SCHEMBL3402356 | 0.81 | SCD (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2290893 | 0.79 | NAMPT (0.53) | NAMPTLMNAOGASNCAHDAC3 | |
| SCHEMBL3404518 | 0.79 | OGA (0.43) | LMNAOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL2295632 | 0.75 | SCD (0.58) | NAMPTSCD | |
| SCHEMBL2295200 | 0.73 | NAMPT (0.51) | NAMPTLMNAOGASNCA | |
| SCHEMBL2290881 | 0.73 | HPGD (0.55) | NAMPTLMNAOGAHDAC3HDAC4 | |
| SCHEMBL8093604 | 0.72 | NAMPT (0.54) | NAMPTLMNASNCAHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152711-B1 | 2 -HETEROARYL- PYRROLO [3, 4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS | SANOFI AVENTIS (FR) | 2010-11-24 | — | — | EP | disclosed |