Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 10/20 | 0.56 |
| ▸ | F10 | P00742 | 5/20 | 0.56 |
| ▸ | PLAT | P00750 | 5/20 | 0.56 |
| ▸ | PLG | P00747 | 4/20 | 0.56 |
| ▸ | PROC | P04070 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | F9 | P00740 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | F7 | P08709 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478576 | 0.85 | F11 (0.75) | F11KLKB1F10PLATPLG | |
| SCHEMBL478578 | 0.85 | F11 (0.75) | F11KLKB1F10PLATPLG | |
| SCHEMBL3416542 | 0.81 | F11 (0.59) | F11KLKB1F10PLATPLG | |
| SCHEMBL3636834 | 0.80 | F11 (0.56) | F11KLKB1F10PLAT | |
| SCHEMBL3435160 | 0.80 | F11 (0.59) | F11KLKB1F10PLATPLG | |
| SCHEMBL478442 | 0.74 | F11 (0.87) | F11KLKB1F10PLATPLG | |
| SCHEMBL478804 | 0.73 | F11 (0.71) | F11KLKB1F10PLATPLG | |
| SCHEMBL3433267 | 0.73 | F11 (0.81) | F11KLKB1F10PLATPLG | |
| SCHEMBL3416282 | 0.72 | F11 (0.58) | F11KLKB1F10PLATPLG | |
| SCHEMBL478982 | 0.72 | F11 (0.69) | F11KLKB1F10PLATPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265601-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009114677-A1 | PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-17 | — | — | WO | disclosed |