Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 11/20 | 0.69 |
| ▸ | F10 | P00742 | 9/20 | 0.69 |
| ▸ | F9 | P00740 | 2/20 | 0.69 |
| ▸ | PLG | P00747 | 2/20 | 0.69 |
| ▸ | PLAT | P00750 | 2/20 | 0.69 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.69 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.69 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.69 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.69 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3401700 | 0.99 | F2 (0.69) | F2F10F9PLGPLAT | |
| SCHEMBL12096038 | 0.97 | F2 (0.65) | F2F10F9PLGPLAT | |
| SCHEMBL1771006 | 0.94 | F2 (0.60) | F2F10F9PLGPLAT | |
| SCHEMBL12096057 | 0.93 | F2 (0.60) | F2F10F9PLGPLAT | |
| SCHEMBL12096378 | 0.92 | F2 (0.60) | F2F10F9PLGPLAT | |
| SCHEMBL12096123 | 0.91 | F2 (0.59) | F2F10F9PLGPLAT | |
| SCHEMBL12095828 | 0.91 | F2 (0.58) | F2F10F9PLGPLAT | |
| SCHEMBL12096013 | 0.91 | F2 (0.58) | F2F10F9PLGPLAT | |
| SCHEMBL12095871 | 0.90 | F2 (0.57) | F2F10F9PLGPLAT | |
| SCHEMBL1770710 | 0.90 | F2 (0.57) | F2F10F9PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637479-B2 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide | SANOFI (FR) | 2017-05-02 | — | — | US | claimed |
| US-9637479-B2 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide | SANOFI (FR) | 2017-05-02 | — | — | US | disclosed |
| US-9637479-B2 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide | SANOFI (FR) | 2017-05-02 | — | — | US | disclosed |
| US-9637479-B2 | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide | SANOFI (FR) | 2017-05-02 | — | — | US | disclosed |
| US-8378092-B2 | Chlorothiophene-amides as inhibitors of coagulation factors Xa and thrombin | SANOFI (FR) | 2013-02-19 | — | — | US | disclosed |
| EP-2254881-B1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI SA (FR) | 2012-09-12 | — | — | EP | disclosed |
| EP-2254881-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009103440-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI-AVENTIS (FR) | 2009-08-27 | — | — | WO | disclosed |