Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 16/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.37 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014397 | 0.95 | MC4R (0.40) | MC4RCYP3A4ABCC8LMNA | |
| SCHEMBL3408856 | 0.81 | MC4R (0.48) | MC4RCYP3A4ABCC8SLC22A1ABCC3 | |
| SCHEMBL2344486 | 0.81 | MC4R (0.48) | MC4RCYP3A4ABCC8SLC22A1ABCC3 | |
| SCHEMBL3014389 | 0.76 | MC4R (0.45) | MC4RCYP3A4ABCC8LMNA | |
| Hydroxyamine SCHEMBL11026958 | 0.75 | TSHR (0.41) | LMNAMAPK1 | |
| SCHEMBL17871701 | 0.75 | MC4R (0.54) | MC4RCYP3A4MAPK1KCNQ2 | |
| SCHEMBL223031 | 0.75 | TSHR (0.43) | LMNAMAPK1 | |
| SCHEMBL1964089 | 0.75 | MC4R (0.54) | MC4RCYP3A4MAPK1KCNQ2 | |
| SCHEMBL442668 | 0.75 | MC4R (0.54) | MC4RCYP3A4MAPK1KCNQ2 | |
| SCHEMBL2904556 | 0.75 | TSHR (0.43) | LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177221-A1 | Process for the preparation of substantially optically pure Repaglinide and precursors thereof | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-04-21 | — | — | EP | disclosed |