Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 10/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3285096 | 0.82 | GRIN2B (0.50) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL5618907 | 0.82 | GRIN2B (0.50) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2D6 | |
| SCHEMBL5454181 | 0.80 | FAAH (0.54) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL635710 | 0.79 | KDM4C (0.37) | GRIN2BCYP2D6 | |
| SCHEMBL6480129 | 0.79 | SMN1; SMN2 (0.60) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL22777447 | 0.79 | SMN1; SMN2 (0.60) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL30401196 | 0.79 | SMN1; SMN2 (0.60) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4673919 | 0.77 | SMN1; SMN2 (0.61) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL28567312 | 0.77 | SMN1; SMN2 (0.61) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13054327 | 0.77 | SMN1; SMN2 (0.61) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254893-A1 | NOVEL 7-SUBSTITUTED DERIVATIVES OF 3-CARBOXY-OXADIAZINO-QUINOLONES, PREPARATION THEREOF AND USE THEREOF AS ANTI-BACTERIAL AGENTS | VETOQUINOL S.A. (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009106967-A1 | NOVEL 7-SUBSTITUTED DERIVATIVES OF 3-CARBOXY-OXADIAZINO-QUINOLONES, PREPARATION THEREOF AND USE THEREOF AS ANTI-BACTERIAL AGENTS | VETOQUINOL SA (FR) | 2009-09-03 | — | — | WO | disclosed |
| EP-1667994-A1 | QUINOLONE ANTIBACTERIAL AGENTS | Warner-Lambert Company LLC (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050119231-A1 | Quinolone antibacterial agents | ELLSWORTH EDMUND L (US) | 2005-06-02 | — | — | US | disclosed |
| US-20050107423-A1 | Quinolone antibacterial agents | ELLSWORTH EDMUND L (US) | 2005-05-19 | — | — | US | disclosed |
| WO-2005026154-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
| WO-2005026165-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119231-A1 | Quinolone antibacterial agents | NQO2, MRPL21, TOP1 | GRIN2B 3871/4885SMN1; SMN2 3447/4885NPC1 1057/4885 |
| US-20050107423-A1 | Quinolone antibacterial agents | NQO2, MRPL21, TOP1 | GRIN2B 3871/4885SMN1; SMN2 3447/4885NPC1 1057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.