Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31181438 | 0.98 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AAPOBEC3AAPOBEC3G | |
| SCHEMBL12987845 | 0.87 | ATM (0.31) | — | |
| SCHEMBL25320473 | 0.87 | ATM (0.31) | — | |
| SCHEMBL12987844 | 0.87 | ATM (0.31) | — | |
| SCHEMBL5139838 | 0.86 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2AAPOBEC3AAPOBEC3G | |
| SCHEMBL9800024 | 0.82 | SERPINE1 (0.41) | ALOX5SERPINE1METAP2GSREPHX1 | |
| SCHEMBL10867518 | 0.82 | SERPINE1 (0.41) | ALOX5SERPINE1METAP2GSREPHX1 | |
| SCHEMBL21019803 | 0.80 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2AAPOBEC3AAPOBEC3G | |
| SCHEMBL23587563 | 0.80 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2AAPOBEC3AAPOBEC3G | |
| SCHEMBL2316033 | 0.79 | CHRM2 (0.41) | ALDH1A1MEN1KMT2AAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |