Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RPLP1 | P05386 | 10/20 | 0.39 |
| ▸ | RPLP0 | P05388 | 10/20 | 0.39 |
| ▸ | RPS17 | P08708 | 10/20 | 0.39 |
| ▸ | RPSA | P08865 | 10/20 | 0.39 |
| ▸ | RPS2 | P15880 | 10/20 | 0.39 |
| ▸ | RPL35A | P18077 | 10/20 | 0.39 |
| ▸ | RPL7 | P18124 | 10/20 | 0.39 |
| ▸ | RPL17 | P18621 | 10/20 | 0.39 |
| ▸ | RPS4Y1 | P22090 | 10/20 | 0.39 |
| ▸ | RPS3 | P23396 | 10/20 | 0.39 |
| ▸ | RPS12 | P25398 | 10/20 | 0.39 |
| ▸ | RPL13 | P26373 | 10/20 | 0.39 |
| ▸ | RPL10 | P27635 | 10/20 | 0.39 |
| ▸ | RPL12 | P30050 | 10/20 | 0.39 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 10/20 | 0.39 |
| ▸ | RPL22 | P35268 | 10/20 | 0.39 |
| ▸ | RPL4 | P36578 | 10/20 | 0.39 |
| ▸ | RPS19 | P39019 | 10/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445165 | 0.87 | RPLP1 (0.35) | MEN1KMT2ARPLP1RPLP0RPS17 | |
| SCHEMBL3412297 | 0.86 | RPLP1 (0.35) | MEN1KMT2ARPLP1RPLP0RPS17 | |
| SCHEMBL3412292 | 0.86 | RPLP1 (0.35) | MEN1KMT2ARPLP1RPLP0RPS17 | |
| SCHEMBL4443619 | 0.86 | RPLP1 (0.35) | MEN1KMT2ARPLP1RPLP0RPS17 | |
| SCHEMBL4438003 | 0.83 | PCSK9 (0.36) | MEN1KMT2ARPLP1RPLP0RPS17 | |
| SCHEMBL4436107 | 0.81 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL1710253 | 0.81 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL3233538 | 0.81 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL3412017 | 0.81 | RPLP1 (0.41) | MEN1KMT2ARPLP1RPLP0RPS17 | |
| SCHEMBL3412423 | 0.81 | MEN1 (0.34) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109576-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2009-09-11 | — | — | WO | disclosed |