Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414879 | 1.00 | MEN1 (0.34) | MEN1KMT2AALDH1A1HTTRAB9A | |
| SCHEMBL1710250 | 0.87 | ALDH1A1 (0.36) | MEN1KMT2AALDH1A1HTTRAB9A | |
| SCHEMBL3415256 | 0.86 | MEN1 (0.32) | MEN1KMT2AALDH1A1HTTRAB9A | |
| SCHEMBL1710475 | 0.86 | KMT2A (0.32) | MEN1KMT2AALDH1A1HTTRAB9A | |
| SCHEMBL3412104 | 0.84 | JAK2 (0.33) | MEN1KMT2AALDH1A1 | |
| SCHEMBL1710274 | 0.84 | GAA (0.33) | MEN1KMT2AALDH1A1HTTRAB9A | |
| SCHEMBL3414887 | 0.81 | KDM4E (0.39) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3410717 | 0.81 | KDM4E (0.39) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3410722 | 0.81 | KDM4E (0.39) | MEN1KMT2AALDH1A1 | |
| SCHEMBL3408546 | 0.81 | MEN1 (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109576-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2009-09-11 | — | — | WO | disclosed |