SCHEMBL3408645

SCHEMBL3408645

O=C(Cc1ccccc1)NC(F)(F)F

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.59
KMT2A Q03164 2/20 0.59
HDAC8 Q9BY41 1/20 0.59
HDAC6 Q9UBN7 1/20 0.59
CES1 P23141 2/20 0.57
EPHX2 P34913 1/20 0.55
HPGD P15428 2/20 0.51
ATM Q13315 1/20 0.51
CNR2 P34972 5/20 0.51
ALDH1A1 P00352 2/20 0.50
RAB9A P51151 1/20 0.50
CES2 O00748 1/20 0.50
AKR1B1 P15121 1/20 0.50
GAA P10253 2/20 0.49
MAPT P10636 1/20 0.47
CNR1 P21554 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8413699 0.98 MEN1 (0.57) MEN1KMT2AHDAC8HDAC6CES1
SCHEMBL7458737 0.87 CES1 (0.52) MEN1KMT2AHDAC8HDAC6CES1
SCHEMBL22489246 0.85 MEN1 (0.55) MEN1KMT2AHDAC8HDAC6CES1
SCHEMBL18448278 0.82 MEN1 (0.52) MEN1KMT2AHDAC8HDAC6CES1
SCHEMBL27874935 0.81 MAPK14 (0.52) MEN1KMT2AHDAC8HDAC6EPHX2
SCHEMBL4778260 0.81 HDAC2 (0.61) KMT2AHDAC8HDAC6ALDH1A1RAB9A
SCHEMBL10986259 0.80 MEN1 (0.59) MEN1KMT2AHDAC8HDAC6CES1
Hydrochloric Acid SCHEMBL6557840 0.79 HDAC2 (0.59) KMT2AHDAC8HDAC6ALDH1A1RAB9A
SCHEMBL7514728 0.78 HDAC1 (0.64) HDAC8HDAC6CES1HPGDRAB9A
SCHEMBL28557436 0.78 MEN1 (0.48) MEN1KMT2AHDAC8HDAC6CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1286967-B1 CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS MERCK SHARP & DOHME (GB) 2006-09-27 EP claimed
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO claimed
CN-116354830-A Process for the preparation of functionalized fluorinated monomers, fluorinated monomers and compositions for the preparation thereof 埃特纳科技有限公司 2023-06-30 CN disclosed
CN-110770271-B Method for preparing functionalized fluorinated monomers, fluorinated monomers and compositions for preparing same 埃特纳科技有限公司 2023-04-18 CN disclosed
CN-110770271-A Method for preparing functionalized fluorinated monomers, fluorinated monomers and compositions for preparing same 埃特纳科技有限公司 2020-02-07 CN disclosed
WO-2010064722-A1 BENZOTHIAZOLE DERIVATIVES AS ANTICANCER AGENTS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-06-10 WO disclosed
EP-1572693-A1 MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS Pharmacia Corporation (US) 2005-09-14 EP disclosed
US-6861432-B2 Piperazine derivatives that destabilize androgen receptors SCHERING AKTIENGESELLSCHAFT (DE) 2005-03-01 US disclosed
WO-2004058762-A1 MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS PHARMACIA CORPORATION (US) 2004-07-15 WO disclosed
WO-2003043983-A1 PIPERAZINE DERIVATIVES DESTABILISING ANDROGEN RECEPTORS SCHERING AKTIENGESELLSCHAFT (DE) 2003-05-30 WO disclosed
EP-1173420-A2 HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY Novuspharma S.p.A. (IT) 2002-01-23 EP disclosed
EP-0996434-A4 KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH ADOLOR CORP (US) 2001-10-10 EP disclosed
EP-1068187-A1 PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION ABBOTT LABORATORIES (US) 2001-01-17 EP disclosed
WO-2000053581-A2 HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY NOVUSPHARMA S.P.A. (IT) 2000-09-14 WO disclosed
EP-0996434-A1 KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH Adolor Corporation (US) 2000-05-03 EP disclosed
WO-1999051580-A1 PYRAZOLE INHIBITORS OF CYTOKINE PRODUCTION ABBOTT LABORATORIES (US) 1999-10-14 WO disclosed
WO-1999003459-A1 KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH ADOLOR CORPORATION (US) 1999-01-28 WO disclosed