Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017226 | 0.93 | HDAC1 (0.66) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL4778260 | 0.89 | HDAC2 (0.61) | HDAC1HDAC2HDAC8HDAC6SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6557840 | 0.88 | HDAC2 (0.59) | HDAC1HDAC2HDAC8HDAC6SMN1; SMN2 | |
| SCHEMBL12376676 | 0.83 | HDAC1 (0.64) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL26393868 | 0.81 | HDAC1 (0.62) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL6463893 | 0.79 | HDAC1 (0.58) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| Phenylbutyrylhydroxamic Acid SCHEMBL1350853 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL3408645 | 0.78 | MEN1 (0.59) | HDAC8HDAC6SMN1; SMN2CES1HPGD | |
| SCHEMBL13611937 | 0.77 | HDAC1 (0.66) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL622139 | 0.77 | HDAC1 (0.70) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |