Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408775 | 1.00 | ALOX5 (0.41) | ALOX5IGF1RAOC3TRPM8MEN1 | |
| SCHEMBL3408769 | 1.00 | ALOX5 (0.41) | ALOX5IGF1RAOC3TRPM8MEN1 | |
| SCHEMBL16791621 | 0.84 | ALOX5 (0.39) | ALOX5TRPM8ROCK1 | |
| SCHEMBL1464039 | 0.83 | IGF1R (0.36) | ALOX5IGF1RAOC3MEN1KMT2A | |
| SCHEMBL15436412 | 0.83 | ALOX5 (0.36) | ALOX5TRPM8ROCK1 | |
| SCHEMBL12746389 | 0.83 | ALOX5 (0.36) | ALOX5IGF1RAOC3MEN1KMT2A | |
| SCHEMBL1464036 | 0.83 | ALOX5 (0.36) | ALOX5IGF1RAOC3MEN1KMT2A | |
| SCHEMBL3206769 | 0.83 | MEN1 (0.44) | ALOX5IGF1RAOC3MEN1KMT2A | |
| SCHEMBL3206771 | 0.83 | MEN1 (0.44) | ALOX5IGF1RAOC3MEN1KMT2A | |
| SCHEMBL3206781 | 0.83 | MEN1 (0.44) | ALOX5IGF1RAOC3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598160-B2 | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2254872-A2 | CYCLOALKYL LACTAME DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009102460-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |