Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.69 |
| ▸ | DRD3 | P35462 | 13/20 | 0.69 |
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | DRD4 | P21917 | 3/20 | 0.68 |
| ▸ | HTR2A | P28223 | 3/20 | 0.68 |
| ▸ | HTR2C | P28335 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.68 |
| ▸ | HTR7 | P34969 | 2/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.68 |
| ▸ | HRH1 | P35367 | 2/20 | 0.68 |
| ▸ | DRD1 | P21728 | 2/20 | 0.68 |
| ▸ | HTR2B | P41595 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | DRD5 | P21918 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408926 | 1.00 | DRD2 (0.69) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3411195 | 0.92 | DRD2 (0.67) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3411196 | 0.92 | DRD2 (0.67) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3409212 | 0.91 | DRD2 (0.65) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3409210 | 0.91 | DRD2 (0.65) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3412520 | 0.88 | DRD2 (0.82) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3412524 | 0.88 | DRD2 (0.82) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3411546 | 0.88 | DRD2 (0.70) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3411543 | 0.88 | DRD2 (0.70) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL3406933 | 0.88 | DRD2 (0.68) | DRD2DRD3HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663996-B1 | (THIO)CARBAMOYL-CYCLOHEXANE DERIVATIVES AS D3/D2 RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2012-06-20 | — | — | EP | claimed |
| US-20100240640-A1 | (THIO) Carbamoyl-Cyclohexane Derivatives as D3/D2 Receptor Antagonists | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2010-09-23 | — | — | US | claimed |
| US-7737142-B2 | trans-1-{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3-methyl-urea, used in the therapy and/or prevention of pathological conditions requiring the modulation of dopamine receptors; high receptivity to dopamine receptors | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2010-06-15 | — | — | US | claimed |
| US-20060229297-A1 | (THIO) Carbamoyl-cyclohexane derivatives as D3/D2 receptor antagonists | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2006-10-12 | — | — | US | claimed |
| EP-1663996-A1 | (THIO)CARBAMOYL-CYCLOHEXANE DERIVATIVES AS D3/D2 RECEPTOR ANTAGONISTS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2006-06-07 | — | — | EP | claimed |
| WO-2005012266-A1 | (THIO) CARBAMOYL-CYCLOHEXANE DERIVATIVES AS D3/D2 RECEPTOR ANTAGONISTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2005-02-10 | — | — | WO | claimed |
| EP-1663996-B1 | (THIO)CARBAMOYL-CYCLOHEXANE DERIVATIVES AS D3/D2 RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2012-06-20 | — | — | EP | disclosed |
| US-7737142-B2 | trans-1-{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-3-methyl-urea, used in the therapy and/or prevention of pathological conditions requiring the modulation of dopamine receptors; high receptivity to dopamine receptors | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2010-06-15 | — | — | US | disclosed |
| US-20060229297-A1 | (THIO) Carbamoyl-cyclohexane derivatives as D3/D2 receptor antagonists | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229297-A1 | (THIO) Carbamoyl-cyclohexane derivatives as D3/D2 receptor antagonists | DRD3, DRD2, TACR2 | DRD2 2/4885DRD3 1/4885HTR1A 172/4885 |
| US-20100240640-A1 | (THIO) Carbamoyl-Cyclohexane Derivatives as D3/D2 Receptor Antagonists | DRD3, DRD2, TACR2 | DRD2 2/4885DRD3 1/4885HTR1A 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.