Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.56 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587106 | 0.92 | MAPT (0.63) | MAPTALDH1A1LMNAGPR119SMN1; SMN2 | |
| SCHEMBL5237966 | 0.87 | MAPT (0.57) | MAPTALDH1A1LMNAGPR119SMN1; SMN2 | |
| SCHEMBL24990320 | 0.84 | MAPT (0.61) | MAPTALDH1A1LMNAGPR119SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2306453 | 0.83 | HIF1A (0.63) | ALDH1A1SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL5573222 | 0.82 | MAPT (0.76) | MAPTALDH1A1LMNAGPR119SMN1; SMN2 | |
| SCHEMBL6181293 | 0.81 | CHRM2 (0.55) | MAPTALDH1A1LMNAGPR119SMN1; SMN2 | |
| SCHEMBL6793394 | 0.81 | RECQL (0.60) | MAPTALDH1A1LMNAGPR119 | |
| SCHEMBL484823 | 0.81 | HIF1A (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL6182019 | 0.80 | GPR119 (0.60) | MAPTALDH1A1LMNAGPR119HRH3 | |
| SCHEMBL15101975 | 0.80 | CHRM1 (0.53) | MAPTALDH1A1LMNAGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254867-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal Gmbh (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009109364-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-09-11 | — | — | WO | disclosed |