Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 4/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404066 | 0.99 | NMBR (0.41) | NMBRTAS1R3TAS1R1LPAR1KDM4E | |
| SCHEMBL3412550 | 0.86 | NMBR (0.43) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3409553 | 0.85 | ALDH1A1 (0.47) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3406377 | 0.85 | ALDH1A1 (0.43) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3407725 | 0.84 | ALDH1A1 (0.48) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3408427 | 0.84 | NMBR (0.44) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3405543 | 0.84 | NMBR (0.41) | NMBR | |
| SCHEMBL3407686 | 0.83 | NMBR (0.42) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3405936 | 0.80 | NMBR (0.47) | NMBRTAS1R3TAS1R1LPAR1ALDH1A1 | |
| SCHEMBL3408378 | 0.74 | NMBR (0.47) | NMBRLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197838-B1 | NOVEL PHENYLUREA DERIVATIVES, INHIBITORS OF THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RES & DEV (FR) | 2013-10-23 | — | — | EP | claimed |
| EP-2197838-A1 | NOVEL PHENYLUREA DERIVATIVES, INHIBITORS OF THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-23 | — | — | EP | claimed |
| WO-2009030746-A1 | NOVEL PHENYLUREA DERIVATIVES, INHIBITORS OF THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | claimed |