Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2471917 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL4276040 | 0.94 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL19877250 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL10261553 | 0.82 | TDP1 (0.47) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL3974693 | 0.82 | TDP1 (0.47) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL2840695 | 0.82 | TDP1 (0.47) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL7949662 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL1517940 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 | |
| SCHEMBL2846951 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2TDP1CHRM2NPC1RAB9A | |
| SCHEMBL12836400 | 0.81 | RECQL (0.44) | SMN1; SMN2MAPTLIN28ATDP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240171-A2 | INHIBITORS OF CARBONIC ANHYDRASE IX | Molecular Insight Pharmaceuticals, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009089383-A2 | INHIBITORS OF CARBONIC ANHYDRASE IX | MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | WO | disclosed |