Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432491 | 0.83 | MAPT (0.39) | CD274TSHRHPGDKMT2AHSD17B10 | |
| SCHEMBL3406684 | 0.79 | ELANE (0.41) | GAAKMT2AMEN1KDM4ESMN1; SMN2 | |
| SCHEMBL3393662 | 0.78 | PPARA (0.40) | MAPTPPARGPPARDPPARA | |
| SCHEMBL137837 | 0.74 | KDM4E (0.42) | GAAKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3409413 | 0.72 | HTR1A (0.46) | TSHRHPGDGAAKMT2AMEN1 | |
| SCHEMBL3397145 | 0.72 | PPARA (0.39) | KMT2AMEN1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4382035 | 0.71 | HDAC4 (0.46) | ERN1TSHRHPGDHSD17B10ALDH1A1 | |
| SCHEMBL4381890 | 0.70 | TSHR (0.40) | TSHRHPGDKMT2AMEN1HSD17B10 | |
| SCHEMBL4385025 | 0.70 | TSHR (0.44) | TSHRHPGDKMT2AHSD17B10ALDH1A1 | |
| SCHEMBL4380714 | 0.69 | HDAC4 (0.44) | ERN1TSHRHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |