Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | GALR1 | P47211 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410125 | 0.99 | GALR2 (0.51) | GALR2MAPK1TAAR1GALR1ROCK2 | |
| SCHEMBL3411061 | 0.82 | SLC2A1 (0.48) | GALR2MAPK1GALR1MAPTKDM4E | |
| SCHEMBL3406844 | 0.81 | GALR2 (0.48) | GALR2MAPK1GALR1MAPTKDM4E | |
| SCHEMBL3410260 | 0.78 | NPC1 (0.53) | MAPK1MAPTKDM4EBRD4 | |
| SCHEMBL4097822 | 0.78 | PSEN1 (0.56) | GALR2MAPK1TAAR1GALR1 | |
| SCHEMBL3410953 | 0.77 | ABCB1 (0.44) | MAPTPOLBTP53 | |
| SCHEMBL4101337 | 0.77 | PSEN1 (0.57) | GALR2MAPK1TAAR1GALR1 | |
| SCHEMBL3412202 | 0.76 | MAPT (0.42) | GALR2MAPTPOLBTP53BRD4 | |
| SCHEMBL3412595 | 0.75 | MAPT (0.41) | MAPTLMNAPOLBTP53 | |
| SCHEMBL3410452 | 0.75 | BRAF (0.44) | GALR2GALR1MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |