Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 11/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.48 |
| ▸ | GALR1 | P47211 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411061 | 0.99 | SLC2A1 (0.48) | GALR2SLC2A1GALR1MEN1ALDH1A1 | |
| SCHEMBL3413403 | 0.91 | IMPDH2 (0.49) | SLC2A1MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL3411892 | 0.91 | SLC2A1 (0.43) | GALR2SLC2A1GALR1MEN1ALDH1A1 | |
| SCHEMBL3412580 | 0.89 | GALR2 (0.44) | GALR2SLC2A1GALR1KDM4EMAPT | |
| SCHEMBL3409900 | 0.88 | AURKA (0.47) | GALR2SLC2A1GALR1AURKAAURKB | |
| SCHEMBL3410528 | 0.88 | GALR2 (0.42) | GALR2SLC2A1GALR1MEN1ALDH1A1 | |
| SCHEMBL3410260 | 0.86 | NPC1 (0.53) | MEN1ALDH1A1KMT2AKDM4EGAA | |
| SCHEMBL3410125 | 0.82 | GALR2 (0.51) | GALR2GALR1KDM4EMAPTMAPK1 | |
| SCHEMBL3406068 | 0.82 | NPC1 (0.46) | MEN1ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL3407955 | 0.81 | NPC1 (0.51) | MEN1KMT2AKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |