⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184363 | 0.75 | — | — | |
| SCHEMBL27489751 | 0.74 | ODC1 (0.35) | — | |
| SCHEMBL27641478 | 0.74 | ODC1 (0.35) | — | |
| SCHEMBL1337335 | 0.74 | ODC1 (0.43) | — | |
| SCHEMBL29040609 | 0.74 | — | — | |
| SCHEMBL17366114 | 0.72 | — | — | |
| SCHEMBL5656511 | 0.70 | — | — | |
| SCHEMBL10851769 | 0.69 | LMNA (0.43) | — | |
| SCHEMBL13048579 | 0.68 | — | — | |
| SCHEMBL29287004 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097625-B2 | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression | SUNOVION PHARMACEUTICALS INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-2343073-A2 | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression | Sepracor Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| US-20070299055-A1 | COMBINATION OF SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION | SEPRACOR INC. (US) | 2007-12-27 | — | — | US | disclosed |
| EP-1691811-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION | Sepracor, Inc. (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-1401423-A4 | METHOD OF TREATING GASTROESOPHAGEAL REFLUX DISEASE AND NOCTURNAL ACID BREAKTHROUGH | DEPOMED DEV LTD (BM) | 2006-08-16 | — | — | EP | disclosed |
| US-20050215521-A1 | Modafinil combination therapy for improving sleep quality | SEPRACOR INC. | 2005-09-29 | — | — | US | disclosed |
| US-20050164987-A1 | Melatonin combination therapy for improving sleep quality | SEPRACOR INC. | 2005-07-28 | — | — | US | disclosed |
| WO-2005063248-A1 | MODAFINIL COMBINATION THERAPY FOR IMPROVING SLEEP QUALITY | SEPRACOR INC. (US) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005060968-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION | SEPRACOR INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| EP-1401423-A1 | METHOD OF TREATING GASTROESOPHAGEAL REFLUX DISEASE AND NOCTURNAL ACID BREAKTHROUGH | Depomed Development, Ltd (GB) | 2004-03-31 | — | — | EP | disclosed |
| US-20030031711-A1 | Method of treating gastroesophageal reflux disease and nocturnal acid breakthrough | ASSERTIO THERAPEUTICS, INC. | 2003-02-13 | — | — | US | disclosed |
| WO-2002096404-A1 | METHOD OF TREATING GASTROESOPHAGEAL REFLUX DISEASE AND NOCTURNAL ACID BREAKTHROUGH | DEPOMED DEVELOPMENT LTD (GB) | 2002-12-05 | — | — | WO | disclosed |