Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412456 | 0.87 | HCRTR1 (0.39) | HCRTR1HCRTR2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL2799399 | 0.85 | HCRTR1 (0.42) | HCRTR1HCRTR2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL3413488 | 0.85 | HCRTR1 (0.43) | HCRTR1HCRTR2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL3417284 | 0.84 | HCRTR2 (0.41) | HCRTR1HCRTR2PIK3CAGRM5 | |
| SCHEMBL3417285 | 0.84 | HCRTR2 (0.41) | HCRTR1HCRTR2PIK3CAGRM5 | |
| SCHEMBL3411958 | 0.84 | HCRTR2 (0.41) | HCRTR1HCRTR2PIK3CAGRM5 | |
| SCHEMBL3412360 | 0.84 | HCRTR2 (0.41) | HCRTR1HCRTR2PIK3CAGRM5 | |
| SCHEMBL3416131 | 0.82 | CDK4 (0.41) | HCRTR1HCRTR2ALDH1A1L3MBTL1GRM5 | |
| SCHEMBL3414065 | 0.82 | CDK4 (0.41) | HCRTR1HCRTR2ALDH1A1L3MBTL1GRM5 | |
| SCHEMBL2924872 | 0.82 | HDAC7 (0.36) | HCRTR1HCRTR2SLC9A1GRM5AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |